反应详情

5-(3-Nitro-2-methoxy-5-methyl-phenyl)thiophene-2-carboxylic acid 24b (0.29 g, 1 mmol) was dissolved in 30 mL of ethyl acetate followed by addition of 0.06 g of palladium on carbon and ammonium formate (0.25 g, 4 mmol). Upon completion of the addition, the reaction mixture was heated to reflux for 45 minutes. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was filtered to remove palladium on carbon. The filtrate was concentrated under reduced pressure and dried to obtain the title compound 5-(3-amino-2-methoxy-5-methyl-phenyl)-thiophene-2-carboxylic acid 24c (0.26 g, yield 99%) as a green solid.

1. additionUpon completion of the addition
2. temperaturethe reaction mixture was heated
3. temperatureto reflux for 45 minutes
4. filtrationThe mixture was filtered
5. customto remove palladium on carbon
6. concentrationThe filtrate was concentrated under reduced pressure
7. customdried