反应详情

4-(3-nitro-2-methoxy-phenyl)-furan-2-carboxylic acid 28c (500 mg, 1.9 mmol) was dissolved in 15 mL of ethyl acetate followed by addition of 100 mg of palladium on carbon and ammonium formate (429 mg, 7.6 mmol). The reaction mixture was heated to reflux for 3 hours. The reaction was monitored by TLC until the disappearance of the starting materials. The mixture was filtered to remove palladium on carbon and concentrated under reduced pressure to obtain the title compound 4-(3-amino-2-methoxy-phenyl)-furan-2-carboxylic acid 28d (325 mg, yield 73.4%) as a yellow oil.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 3 hours
3. filtrationThe mixture was filtered
4. customto remove palladium on carbon
5. concentrationconcentrated under reduced pressure