Sodium Hydroxide → 2-[(heptylsulfonyl)methyl]-3-methylquinolin-4(1H)-one

HRID 384495노트

반응식

HRID 384495 반응식
[CH2:1]([S:8][CH2:9][C:10]1[NH:11][C:12]2[C:17]([C:18](=[O:21])[C:19]=1[CH3:20])=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].ClC1C=CC=C(C(OO)=[O:30])C=1.[OH-:33].[Na+]>C(Cl)(Cl)Cl>[CH2:1]([S:8]([CH2:9][C:10]1[NH:11][C:12]2[C:17]([C:18](=[O:21])[C:19]=1[CH3:20])=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:30])=[O:33])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 70297m-Chloroperbenzoic acidHCID 595272552-[(heptylsulfanyl)methyl]-3-methylquinolin-4(1H)-one

생성물 1

HCID 595273132-[(heptylsulfonyl)methyl]-3-methylquinolin-4(1H)-one

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a solution of 2-[(heptylsulfanyl)methyl]-3-methylquinolin-4(1H)-one (110 mg) in chloroform (5 mL) was added m-chloroperbenzoic acid (75%, 200 mg) at room temperature, and the mixture was stirred for 5 hours. A 0.2M aqueous sodium hydroxide solution (20 mL) was added to the reaction mixture, followed by extraction with chloroform (50 mL). The organic layer was washed sequentially with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the resulting powder was washed with diethyl ether and dried to obtain 2-[(heptylsulfonyl)methyl]-3-methylquinolin-4(1H)-one (70 mg).

후처리

  1. extractionfollowed by extraction with chloroform (50 mL)
  2. washThe organic layer was washed sequentially with water and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure
  5. washthe resulting powder was washed with diethyl ether
  6. customdried

출처 및 근거

ORD 기록
ord-f5aa24a2fd01447f90df67d8f2fdce68
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08367702B2

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