反应详情

To a solution of 2-[(heptylsulfanyl)methyl]-3-methylquinolin-4(1H)-one (110 mg) in chloroform (5 mL) was added m-chloroperbenzoic acid (75%, 200 mg) at room temperature, and the mixture was stirred for 5 hours. A 0.2M aqueous sodium hydroxide solution (20 mL) was added to the reaction mixture, followed by extraction with chloroform (50 mL). The organic layer was washed sequentially with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the resulting powder was washed with diethyl ether and dried to obtain 2-[(heptylsulfonyl)methyl]-3-methylquinolin-4(1H)-one (70 mg).

1. extractionfollowed by extraction with chloroform (50 mL)
2. washThe organic layer was washed sequentially with water and saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. washthe resulting powder was washed with diethyl ether
6. customdried