反应详情

温度

95 °C

Methyl 3-cyano-4-hydroxy-5-iodobenzoate (1.00 g) was dissolved in 1,4-dioxane (15 mL), and potassium carbonate (1.31 g), cyclopropylboronic acid (325 mg) and [1,3-bis-(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium dichloride (108 mg) were added to the solution, and then the mixture was stirred under an argon gas flow at 95° C. for 22 hours. The reaction solution was filtered and the solvent was distilled off under reduced pressure, and then the obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1) to obtain the title compound (348 mg) as a pale yellow crystal.

1. filtrationThe reaction solution was filtered
2. distillationthe solvent was distilled off under reduced pressure
3. customthe obtained residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=4:1)