Oxalyl chloride → HCID 86668177, compound

HRID 385121Notes

Reaction equation

HRID 385121 reaction equation
[CH3:1][O:2][C:3]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:6]([C:7](O)=[O:8])=[CH:5][C:4]=1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:17].C(Cl)(=O)C([Cl:26])=O>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:6]([C:7]([Cl:26])=[O:8])=[CH:5][C:4]=1[C:16]([N:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1)=[O:17]

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 68108612HCID 68108612, compound

Product 1

HCID 86668177HCID 86668177, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To 4-methoxy-3-(pyrrolidine-1-carbonyl)-5-trifluoromethylbenzoic acid (785 mg), toluene (8 mL) and oxalyl chloride (0.64 mL) were added, and then the mixture was stirred at room temperature for 22 hours. The solvent was distilled off under reduced pressure and the obtained product was used for the synthesis of (d).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe obtained product was used for the synthesis of (d)

Sources & evidence

ORD record
ord-348a273fc74649e3a137eb1da298f248
Source dataset
uspto-grants-2013_02
Patent number
US08367843B2

Reaction notes

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