Water → HCID 68107964, compound

HRID 385151Notes

Reaction equation

HRID 385151 reaction equation
COC[O:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][C:6]=1[O:15][C:16]([F:19])([F:18])[F:17].FC(F)(F)C(O)=O.O>C(Cl)(Cl)Cl>[OH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][C:6]=1[O:15][C:16]([F:17])([F:18])[F:19]

Participants

5

Reactant 3

HCID 962WaterHCID 6422Trifluoroacetic acidHCID 68108142HCID 68108142, compound

Product 1

HCID 68107964HCID 68107964, compoundYield 69.6%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Methyl 4-methoxymethoxy-3-trifluoromethoxybenzoate (590 mg) was dissolved in chloroform (10 mL), and trifluoroacetic acid (5 mL) was added to the solution, and then the mixture was stirred at room temperature for 1 hour. Water was added to the solution, and then the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and then dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure and the obtained residue was washed with n-hexane to obtain the title compound (346 mg) as a colorless crystal.

Workup

  1. extractionthe mixture was extracted with chloroform
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. distillationThe solvent was distilled off under reduced pressure
  5. washthe obtained residue was washed with n-hexane

Sources & evidence

ORD record
ord-62f8afda364644d493986c5a4df5f9b1
Source dataset
uspto-grants-2013_02
Patent number
US08367843B2

Reaction notes

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