反应详情

温度

80 °C

tert-Butyl 4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-5,8-dihydrothieno[2,3-b:5,4-c′]dipyridine-7(6H)-carboxylate from Example 54A (250 mg, 0.365 mmol) was dissolved in 2-propanol (2 mL), and 4 M gaseous hydrogen chloride in dioxane (0.18 mL, 0.72 mmol) was added. The mixture was stirred at 80° C. for 1.5 h. The solvent was removed, and the residue was treated with 1 M aqueous sodium hydroxide solution (5 mL). The precipitate was collected by suction filtration, washed with water and dried in vacuo to yield 138 mg (99%) of the title compound.

1. customThe solvent was removed
2. additionthe residue was treated with 1 M aqueous sodium hydroxide solution (5 mL)
3. filtrationThe precipitate was collected by suction filtration
4. washwashed with water
5. customdried in vacuo