反应详情

温度

80 °C

tert-Butyl(3,4-dichloro-5-hydroxyphenyl)carbamate from Example 67A (960 mg, 3.45 mmol) was dissolved in 2-propanol (16 mL), and 4 M gaseous hydrogen chloride in dioxane (5.0 mL, 20 mmol) was added. The mixture was heated to 80° C. for 1.5 h. Subsequently, the solvent was removed in vacuo to yield 700 mg (90%) of the title compound.

1. customSubsequently, the solvent was removed in vacuo