反应详情

温度

50 °C

To a suspension of Example 59A (100 mg, 0.20 mmol) in DMF (2 mL) was added azetidine (23 mg, 0.40 mmol), and the mixture was heated to 50° C. for 1 h. It was then diluted with methyl tert-butyl ether, washed with water and dried over sodium sulfate. The solvent was removed in vacuo, and the residue was purified by preparative HPLC to yield 12.4 mg (13%) of the title compound.

1. washwashed with water
2. dry with materialdried over sodium sulfate
3. customThe solvent was removed in vacuo
4. customthe residue was purified by preparative HPLC