Potassium Hydroxide → HCID 86646269, compound

HRID 385905Notes

Reaction equation

HRID 385905 reaction equation
C[O:2][C:3](=[O:16])[CH:4]([O:12]C(=O)C)[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([Br:11])[N:6]=1.[OH-].[K+:18]>C1COCC1.CO>[Br:11][C:7]1[N:6]=[C:5]([CH:4]([OH:12])[C:3]([O-:16])=[O:2])[CH:10]=[CH:9][CH:8]=1.[K+:18]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 59525561HCID 59525561, compound

Product 1

HCID 86646269HCID 86646269, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl(acetyloxy)(6-bromopyridin-2-yl)acetate (1.36 g, 4.70 mmol) in THF (20 mL) and MeOH (10 mL) was added aqueous KOH (1.0 M, 9.88 mL, 9.88 mmol). The solution was stirred at room temperature for 2 hours and then the solvent was evaporated to give the title compound as a colorless solid which was carried on without purification.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-00236ba7b9904013bf84a9c13c0d6603
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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