Hydrochloric Acid → Morpholine-3-carboxylic acid amide hydrochloride

HRID 385989Notes

Reaction equation

HRID 385989 reaction equation
[NH2:1][C:2]([CH:4]1[CH2:9][O:8][CH2:7][CH2:6][N:5]1C(OC(C)(C)C)=O)=[O:3].O1CCOCC1.[ClH:23]>>[ClH:23].[NH:5]1[CH2:6][CH2:7][O:8][CH2:9][CH:4]1[C:2]([NH2:1])=[O:3]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21098189tert-Butyl 3-carbamoylmorpholine-4-carboxylate

Product 1

HCID 67166308Morpholine-3-carboxylic acid amide hydrochloride

Procedure

1,1-Dimethylethyl 3-(aminocarbonyl)morpholine-4-carboxylate (0.48 g, 2.085 mmol) was taken up in 4 M HCl in dioxane (5 mL, 10.00 mmol) and maintained at room temperature overnight. The solvent was removed in vacuo to afford the title compound as a pale yellow solid.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-11ae47b014e3454b84fe5e46e12c8be8
Source dataset
uspto-grants-2013_02
Patent number
US08367706B2

Reaction notes

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