反应详情

5-[4-(1-Cyano-1-methylethyl)phenyl]-2-({2-[2-(trimethylsilyl)ethoxy]pyrimidin-4-yl}amino)thiophene-3-carboxamide (107 mg, 0.223 mmol) was stirred in a mixture of DCM (5 mL) and TFA (2 mL) at room temperature for 30 minutes. Saturated NaHCO3 was added and the resulting precipitate collected by filtration and washed with water and DCM to give the title compound as a yellow solid.

1. filtrationthe resulting precipitate collected by filtration
2. washwashed with water and DCM