反应详情

3-(4′-Propyl-bicyclohexyl-4-yl)-propan-1-ol (5 g, 18.8 mmol) is dissolved in dichloromethane (50 ml) and triethylamine (3.5 ml) and a solution of methacryloyl chloride (2.2 ml, 21.8 mmol) in dichloromethane (30 ml) is added dropwise at 0° C. The reaction is stirred overnight, evaporated, filtered through silica with heptane/ethyl acetate (19:1) and the crude product is crystallised from ethanol to give 2-methyl acrylic acid 3-(4′-propyl-bicyclohexyl-4-yl)-propyl ester as colourless crystals.

1. customevaporated
2. filtrationfiltered through silica with heptane/ethyl acetate (19:1)
3. customthe crude product is crystallised from ethanol