反应详情

NaOH (60% oil, 30 mg, 0.61 mmol) was added to a solution of 5-(1H-benzo[d][1,2,3]triazol-1-yl)-4-(naphthalen-1-yl)-1,2,3-thiadiazole and methylthioglycolate (64 mg, 0.61 mmol) in DMF (3 mL) and the mixture was stirred at room temperature for 2 h. 1N HCl was then added and the mixture was extracted with ethyl acetate, dried over Na2SO4 and concentrated. Purification by TLC (100% DCM) afforded methyl 2-(4-(naphthalen-1-yl)-1,2,3-thiadiazol-5-ylthio)acetate.

1. extractionthe mixture was extracted with ethyl acetate
2. dry with materialdried over Na2SO4
3. concentrationconcentrated
4. customPurification by TLC (100% DCM)