Hydrochloric Acid → HCID 67445916, compound

HRID 386539Notes

Reaction equation

HRID 386539 reaction equation
[CH3:1][C@H:2]1[CH2:7][C@@H:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=3)[C:11](=[O:25])[CH:10]=2)[CH2:5][CH2:4][N:3]1C(OC(C)(C)C)=O.[ClH:33]>CO>[ClH:33].[CH3:1][C@H:2]1[CH2:7][C@@H:6]([O:8][C:9]2[CH:14]=[CH:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][CH:16]=3)[C:11](=[O:25])[CH:10]=2)[CH2:5][CH2:4][NH:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730203HCID 131730203, compound

Product 1

HCID 67445916HCID 67445916, compoundYield 134.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of cis-tert-butyl 2-methyl-4-(1-(4-(methylsulfonyl)phenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate (98.9 mg, 0.214 mmol) in MeOH (1.0 mL) at 0° C. was added hydrochloric acid (2.0 mL, 8.00 mmol, 4.0 M in dioxane, Aldrich). The reaction mixture was warmed up to room temperature and continuously stirred at room temperature. After stirring for 1.5 hrs, the mixture was evaporated under reduced pressure to give the title compound (114.5 mg) as an off-white solid. This material was used in the next step without further purification. MS (ESI) 363 (M+H).

Workup

  1. stirringAfter stirring for 1.5 hrs
  2. customthe mixture was evaporated under reduced pressure

Sources & evidence

ORD record
ord-95fb0b89eb9c450b8f8a9b60a5854608
Source dataset
uspto-grants-2013_02
Patent number
US08372837B2

Reaction notes

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