Thioacetamide → HCID 86643377, compound

HRID 386745Notes

Reaction equation

HRID 386745 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH2:14][C:13]([C:19]3[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([Cl:26])[CH:20]=3)([C:15]([F:18])([F:17])[F:16])[O:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[CH2:8]Br.[C:27]([NH2:30])(=[S:29])[CH3:28]>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH2:14][C:13]([C:19]3[CH:24]=[C:23]([Cl:25])[CH:22]=[C:21]([Cl:26])[CH:20]=3)([C:15]([F:16])([F:18])[F:17])[O:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][NH:30][C:27](=[S:29])[CH3:28]

Participants

3

Reactant 2

HCID 2723949ThioacetamideHCID 866433713-[3-Bromo-4-(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole

Product 1

HCID 86643377HCID 86643377, compoundYield 32.1%

Conditions

Temperature
80 °C

Procedure

3-[3-bromo-4-(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (0.3 g) was mixed with thioacetamide (0.04 g), and the mixture was then stirred for one hour at 80° C. The residue was purified by silica gel chromatography to yield N-{2-bromo-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzyl}ethanethioamide (0.09 g).

Workup

  1. customThe residue was purified by silica gel chromatography

Sources & evidence

ORD record
ord-c7c9b60df562482a8581046a97e83b49
Source dataset
uspto-grants-2013_02
Patent number
US08372867B2

Reaction notes

Loading…