反应详情

A solution of 4,4,4-trifluoro-3-hydroxy-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]butan-1-one (1.0 g), hydroxylamine hydrochloride (0.28 g) and pyridine (0.42 g) in ethanol (10 mL) was heated to reflux for 5 hours. After the reaction solution was diluted with t-butylmethylether, the solution was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to yield 4,4,4-trifluoro-3-hydroxy-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]butan-1-one oxime (1.0 g).

1. temperatureto reflux for 5 hours
2. washthe solution was washed with water and saturated brine
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. distillationThe solvent was distilled off under reduced pressure