HRID387033

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID70544

1-(2,4-Xylyl)piperazine

C12H18N2

HCID81531

Diisopropylethylamine

C8H19N

HCID5049666

Sodium triacetoxyborohydride

C6H10BNaO6

HCID86639919

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2cc(CCCN3CCN(c4ccc(C)cc4C)CC3)nn2C(C)(C)C)cc1

HCID25065877

未命名化合物

PROCEDURE

实验过程

109 mg (74%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-tert-butyl-5-(4-methoxyphenyl)-1H-pyrazol-3-yl)propanal (85 mg, 0.297 mmol), 1-(2,4-dimethylphenyl)piperazine (57 mg, 0.297 mmol), DIPEA (0.078 mL, 0.446 mmol) and NaBH(OAc)3 (189 mg, 0.891 mmol).

WORKUP

后处理

custom109 mg (74%) of target compound was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a4d3675909d54732a5cb3e4899841d4e
来源数据集: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08372844B2
来源说明: uspto-grants-2013_02

反应 SMILES

[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:8][C:7]([CH2:18][CH2:19][CH:20]=O)=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[CH3:22][C:23]1[CH:28]=[C:27]([CH3:29])[CH:26]=[CH:25][C:24]=1[N:30]1[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]1.CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[C:1]([N:5]1[C:9]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[CH:8][C:7]([CH2:18][CH2:19][CH2:20][N:33]2[CH2:34][CH2:35][N:30]([C:24]3[CH:25]=[CH:26][C:27]([CH3:29])=[CH:28][C:23]=3[CH3:22])[CH2:31][CH2:32]2)=[N:6]1)([CH3:4])([CH3:3])[CH3:2]