Diisopropylethylamine → HCID 68554288, compound

HRID 387150Notes

Reaction equation

HRID 387150 reaction equation
[C:1]1([N:7]2[C:11]([CH2:12][CH2:13][CH:14]=O)=[CH:10][C:9]([CH2:16][CH2:17][CH3:18])=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:19][C:20]1[CH:21]=[C:22]([N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH:23]=[CH:24][C:25]=1[Cl:26].CCN(C(C)C)C(C)C.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[Cl:19][C:20]1[CH:21]=[C:22]([N:27]2[CH2:32][CH2:31][N:30]([CH2:14][CH2:13][CH2:12][C:11]3[N:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[N:8]=[C:9]([CH2:16][CH2:17][CH3:18])[CH:10]=3)[CH2:29][CH2:28]2)[CH:23]=[CH:24][C:25]=1[Cl:26]

Participants

5

Reactant 4

HCID 81531DiisopropylethylamineHCID 936011-(3,4-Dichlorophenyl)piperazineHCID 5049666Sodium triacetoxyborohydrideHCID 866399323-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal

Product 1

HCID 68554288HCID 68554288, compound

Procedure

192 mg (94%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-phenyl-3-propyl-1H-pyrazol-5-yl)propanal (100 mg, 0.413 mmol), 1-(3,4-dichlorophenyl)piperazine (95 mg, 0.413 mmol), DIPEA (0.110 mL, 0.620 mmol) and NaBH(OAc)3 (263 mg, 1.239 mmol).

Workup

  1. custom192 mg (94%) of target compound was obtained

Sources & evidence

ORD record
ord-f9b0a74a3ea64028bf8a62544dbb65c1
Source dataset
uspto-grants-2013_02
Patent number
US08372844B2

Reaction notes

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