1-(2-Fluorophenyl)piperazine → HCID 68556566, compound

HRID 387166Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:13]([CH2:14][CH2:15][CH:16]=O)=[CH:12][C:11]([CH2:18][CH2:19][CH2:20][CH3:21])=[N:10]2)=[CH:5][CH:4]=1.[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+]>>[F:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[N:29]1[CH2:34][CH2:33][N:32]([CH2:16][CH2:15][CH2:14][C:13]2[N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[N:10]=[C:11]([CH2:18][CH2:19][CH2:20][CH3:21])[CH:12]=2)[CH2:31][CH2:30]1

Participants

Reactant 3

HCID 705291-(2-Fluorophenyl)piperazine

HCID 5049666Sodium triacetoxyborohydride

HCID 86639945HCID 86639945, compound

Product 1

HCID 68556566HCID 68556566, compound

Procedure

308 mg (78%) of target compound was obtained by using a method same as in Example 1 by using 3-(1-(4-methoxyphenyl)-3-butyl-1H-pyrazol-5-yl)propanal (251 mg, 0.876 mmol), 1-(2-fluorophenyl)piperazine (208 mL, 1.314 mmol), and NaBH(OAc)3 (198 mg, 0.936 mmol).

Workup

custom308 mg (78%) of target compound was obtained

Sources & evidence

ORD record: ord-ead3510477d444de9d0bd2d48e1cf9f5
Source dataset: uspto-grants-2013_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08372844B2

Reaction notes

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