反应详情

6,7-Dimethoxy-4-((5-nitro-2-pyridyl)oxy)quinoline (654 mg, 2.00 mmol), iron powder (559 mg, 10.0 mmol) and ammonium chloride (1.07 g, 20.0 mmol) were heated and stirred in ethanol (20 ml)-water (5 ml) at 80° C. for 20 minutes. After completion of the reaction, the reaction mixture was filtered with celite and washed in ethyl acetate. After washing the organic layer with water and saturated saline and drying over anhydrous magnesium sulfate, the drying agent was filtered out and the filtrate was distilled off under reduced pressure. The obtained crude product was suspended in ethyl acetate, the suspension was diluted with hexane, and the crystals were filtered out and washed with ethyl acetate and then blow-dried to obtain the title compound (380 mg, 1.28 mmol, 64%) as light yellow crystals.

1. customAfter completion of the reaction
2. filtrationthe reaction mixture was filtered with celite
3. washwashed in ethyl acetate
4. washAfter washing the organic layer with water and saturated saline
5. dry with materialdrying over anhydrous magnesium sulfate
6. filtrationthe drying agent was filtered out
7. distillationthe filtrate was distilled off under reduced pressure
8. customThe obtained crude product
9. filtrationthe crystals were filtered out
10. washwashed with ethyl acetate
11. customblow-dried