Hydrochloric Acid → HCID 58931116, compound

HRID 387775Notes

Reaction equation

HRID 387775 reaction equation
C(O)C.O.[OH-].[Li+].C([O:9][C:10]([C:12]1[NH:38][C:15]2[N:16]=[CH:17][N:18]=[C:19]([O:20][C:21]3[CH:26]=[CH:25][C:24]([NH:27][C:28]([NH:30][C:31]4[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=4)=[O:29])=[CH:23][CH:22]=3)[C:14]=2[CH:13]=1)=[O:11])C.Cl>O>[F:37][C:34]1[CH:35]=[CH:36][C:31]([NH:30][C:28](=[O:29])[NH:27][C:24]2[CH:25]=[CH:26][C:21]([O:20][C:19]3[C:14]4[CH:13]=[C:12]([C:10]([OH:11])=[O:9])[NH:38][C:15]=4[N:16]=[CH:17][N:18]=3)=[CH:22][CH:23]=2)=[CH:32][CH:33]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 168937Lithium hydroxide, monohydrateHCID 58930909HCID 58930909, compound

Product 1

HCID 58931116HCID 58931116, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
42.5 °C

Procedure

After adding 7 ml of ethanol, 7 ml of water and 31 mg of lithium hydroxide monohydrate to 75 mg of the 4-{4-[3-(4-fluorophenyl)ureido]phenoxy)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid ethyl ester synthesized in Example 163 and stirring the mixture at 40-45° C. for 24 hours, it was neutralized with 2N HCl and concentrated to dryness to obtain 40 mg of the title compound.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-68aa816106d547c8a5063690ade9ed2f
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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