8-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione → 8-(2-Methoxy-4-cyano-phenyl)-1H,3H-purin-2,6-dione

HRID 3878Notes

Reaction equation

HRID 3878 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=O)[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1>P(Cl)(Cl)(Cl)=O>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]#[N:11])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:18](=[O:21])[NH:17][C:16](=[O:22])[NH:15][C:14]=2[N:13]=1

Participants

3

Reactant 1

HCID 201532438-(2-Methoxy-4-aminocarbonyl-phenyl)-1H,3H-purin-2,6-dione

Product 1

HCID 201532568-(2-Methoxy-4-cyano-phenyl)-1H,3H-purin-2,6-dione

Reagents, catalysts & solvents 1

HCID 24813Phosphorus oxychlorideSolvent

Procedure

Prepared by boiling 0.7 gm of 8-(2-methoxy-4-aminocarbonylphenyl)-1H,3H-purin-2,6-dione in 10 ml of phosphorus oxychloride for 24 hours. The compound crystallizes as the hemihydrate.

Workup

  1. customPrepared
  2. customfor 24 hours
  3. customThe compound crystallizes as the hemihydrate

Sources & evidence

ORD record
ord-659dfef79a1345f9a27aa0d9cf9068c9
Source dataset
uspto-grants-1988_02
Patent number
US04722929

Reaction notes

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