反应详情

温度

160 °C

A mixture of 15.88 g of 2-amino-4-chloropyridine 34.5 g of p-nitrophenol, 52 ml of Hunig's base and 100 ml of 1-methyl-2-pyrrolidinone was stirred at 160° C. for 15 hours. Water was added, extraction was performed with ethyl acetate, and the solvent was distilled off under reduced pressure. The residue was purified by column chromatography (hexane:ethyl acetate=1:1) using NH type silica gel to obtain 3.24 g of the target substance as a light yellow solid.

1. extractionextraction
2. distillationthe solvent was distilled off under reduced pressure
3. customThe residue was purified by column chromatography (hexane:ethyl acetate=1:1)
4. customto obtain 3.24 g of the target substance as a light yellow solid