Hydrochloric Acid → HCID 58930907, compound

HRID 387924Notes

Reaction equation

HRID 387924 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][C:9]([NH:11][C:12]1[CH:17]=[C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)=[O:27])=[CH:21][CH:20]=2)[CH:15]=[CH:14][N:13]=1)=[O:10])=[O:5])C.[OH-].[Na+].CO.Cl>CN(C)C=O>[C:4]([CH2:6][CH2:7][CH2:8][C:9]([NH:11][C:12]1[CH:17]=[C:16]([O:18][C:19]2[CH:24]=[CH:23][C:22]([NH:25][C:26]([NH:28][C:29]3[CH:30]=[CH:31][C:32]([F:35])=[CH:33][CH:34]=3)=[O:27])=[CH:21][CH:20]=2)[CH:15]=[CH:14][N:13]=1)=[O:10])([OH:5])=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 58930891HCID 58930891, compound

Product 1

HCID 58930907HCID 58930907, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

N-{4-[2-(4-Ethoxycarbonylbutyryl)aminopyridin-4-yl]oxyphenyl}-N′-(4-fluorophenyl)urea (22 mg), 2N aqueous sodium hydroxide (1 ml), methanol (2 ml) and dimethylformamide (1 ml) were stirred together at 80° C. for 20 minutes. After returning the mixture to room temperature, 0.4 ml of 5N aqueous hydrochloric acid was added and the precipitated solid was filtered out to obtain 16 mg of the target substance as a white solid.

Workup

  1. customto room temperature
  2. filtrationthe precipitated solid was filtered out
  3. customto obtain 16 mg of the target substance as a white solid

Sources & evidence

ORD record
ord-ac5ba77c8d7c483e96989cb375a13416
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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