反应详情

4-Chloro-2-carboxypyridine (2.0 g), (aminomethyl)cyclopropane hydrochloride (1.7 g), 1-ethyl-3-(3-diethylaminopropyl)carbodiimide hydrochloride (WSC) (2.9 g), 1-hydroxybenzotriazole (HOBt) (2.3 g), triethylamine (2.1 ml) and tetrahydrofuran (30 ml) were stirred together at room temperature for 2 hours. Water was added, extraction was performed with ethyl acetate, and then silica gel was added to the extract and the solvent was distilled off under reduced pressure. The silica gel was charged into a dry column packed with silica gel and purified by column chromatography (hexane:ethyl acetate=4:1, followed by 2:1) to obtain 1.5 mg of the target substance as a yellow oil.

1. extractionextraction
2. additionsilica gel was added to the
3. extractionextract
4. distillationthe solvent was distilled off under reduced pressure
5. additionThe silica gel was charged into a dry column
6. custompurified by column chromatography (hexane:ethyl acetate=4:1, followed by 2:1)
7. customto obtain 1.5 mg of the target substance as a yellow oil