反应详情

温度

100 °C

A mixture of 0.6 g of 2-butyrylamino-4-(4-nitrophenoxy)pyridine, 1.2 g of iron powder, 2.8 g of ammonium chloride, 10 ml of ethanol, 10 ml of dimethylformamide and 5 ml of water was vigorously stirred at 100° C. for 10 minutes. The reaction was filtered with celite, the solvent was distilled off under reduced pressure, and then water was added to the filtrate and extraction was performed with ethyl acetate. The extract was dried over magnesium sulfate and the solvent distilled off under reduced pressure to obtain 0.6 g of the target substance as a light yellow solid.

1. filtrationThe reaction was filtered with celite
2. distillationthe solvent was distilled off under reduced pressure
3. additionwater was added to the filtrate and extraction
4. dry with materialThe extract was dried over magnesium sulfate
5. distillationthe solvent distilled off under reduced pressure
6. customto obtain 0.6 g of the target substance as a light yellow solid