HCID 22936653, compound → HCID 22936372, compound

HRID 387944Notes

Reaction equation

HRID 387944 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[N:10]=[CH:9][CH:8]=[C:7]2[O:16][C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[C:19]([C:26]([F:29])([F:28])[F:27])[CH:18]=1)(=[O:3])[NH2:2]>O1CCCC1.CO.[C].[Pd]>[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[CH:12][C:13]=1[O:14][CH3:15])[N:10]=[CH:9][CH:8]=[C:7]2[O:16][C:17]1[CH:22]=[CH:21][C:20]([NH2:23])=[C:19]([C:26]([F:28])([F:29])[F:27])[CH:18]=1)(=[O:3])[NH2:2]

Participants

5

Reactant 1

HCID 22936653HCID 22936653, compound

Product 1

HCID 22936372HCID 22936372, compoundYield 107.9%

Reagents, catalysts & solvents 3

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

After dissolving 6-carbamoyl-4-(3-trifluoromethyl-4-nitrophenoxy)-7-methoxyquinoline (0.60 g) in tetrahydrofuran (10 ml) and methanol (10 ml), the solution was subjected to catalytic reduction with palladium-carbon (600 mg) for 10 hours under a hydrogen atmosphere to obtain the title compound (0.60 g).

Sources & evidence

ORD record
ord-bd6dd26f9d49488d92bf1fca9b792654
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

Loading…