4-(4-Nitrophenoxy)furo[2,3-b]pyridine-2-carboxylic acid methyl ester → 4-(4-Aminophenoxy)furo[2,3-b]pyridine-2-carboxylic acid methyl ester

HRID 387970Notes

Reaction equation

HRID 387970 reaction equation
[CH3:1][O:2][C:3]([C:5]1[O:23][C:8]2=[N:9][CH:10]=[CH:11][C:12]([O:13][C:14]3[CH:19]=[CH:18][C:17]([N+:20]([O-])=O)=[CH:16][CH:15]=3)=[C:7]2[CH:6]=1)=[O:4]>[Fe]>[CH3:1][O:2][C:3]([C:5]1[O:23][C:8]2=[N:9][CH:10]=[CH:11][C:12]([O:13][C:14]3[CH:19]=[CH:18][C:17]([NH2:20])=[CH:16][CH:15]=3)=[C:7]2[CH:6]=1)=[O:4]

Participants

3

Reactant 1

HCID 589314974-(4-Nitrophenoxy)furo[2,3-b]pyridine-2-carboxylic acid methyl ester

Product 1

HCID 589314624-(4-Aminophenoxy)furo[2,3-b]pyridine-2-carboxylic acid methyl esterYield 86.9%

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

4-(4-Nitrophenoxy)-furo[2,3-b]pyridine-2-carboxylic acid methyl ester (70 mg) was subjected to iron reduction by the same method as in Production Example 10 to obtain the title compound (55 mg).

Sources & evidence

ORD record
ord-83b0dcbffd874c94bf3da17223e2f72d
Source dataset
uspto-grants-2013_02
Patent number
US08372981B2

Reaction notes

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