1-Butanol → 6-(4-Hydroxyphenyl)-1-(2-morpholinoethyl)-1H-imidazo[4,5-B]pyrazin-2(3H)-one

HRID 388112Notes

Reaction equation

HRID 388112 reaction equation
Br[C:2]1[N:7]=[C:6]([NH:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[C:5]([NH2:17])=[N:4][CH:3]=1.BrC1N=[C:21](N)[C:22](N)=NC=1.[O:27]1CCN(CCN)C[CH2:28]1.C(N(C(C)C)CC)(C)C.[CH2:45]([OH:49])[CH2:46][CH2:47][CH3:48]>>[OH:49][C:45]1[CH:22]=[CH:21][C:48]([C:2]2[N:7]=[C:6]3[N:8]([CH2:9][CH2:10][N:11]4[CH2:16][CH2:15][O:14][CH2:13][CH2:12]4)[C:28](=[O:27])[NH:17][C:5]3=[N:4][CH:3]=2)=[CH:47][CH:46]=1

Participants

6

Reactant 5

HCID 2631-ButanolHCID 81531DiisopropylethylamineHCID 4082852-MorpholinoethylamineHCID 27718575-Bromopyrazine-2,3-diamineHCID 717297036-Bromo-N2-(2-morpholinoethyl)pyrazine-2,3-diamine

Product 1

HCID 1358710166-(4-Hydroxyphenyl)-1-(2-morpholinoethyl)-1H-imidazo[4,5-B]pyrazin-2(3H)-oneYield 88%

Procedure

6-Bromo-N2-(2-morpholinoethyl)pyrazine-2,3-diamine. In a sealed tube, a solution of 5-bromopyrazine-2,3-diamine (5.0 g, 19.7 mmol), 2-morpholinoethanamine (5.14 g, 39.5 mmol), diisopropylethylamine (6.9 mL, 39.5 mmol) in n-butanol (100 mL) was heated at 120° C. for 17 h. The volatiles were removed under reduced pressure. The residue was taken up in hexanes and diethylether and sonicated. The resulting precipitate was collected by filtration to provide the title compound (5.23 g, 88%). MS (ESI) m/z 304.2 [M+1]+.

Workup

  1. customThe volatiles were removed under reduced pressure
  2. customdiethylether and sonicated
  3. filtrationThe resulting precipitate was collected by filtration

Sources & evidence

ORD record
ord-341ec88175f543e1b8b7cd1f22efc8b3
Source dataset
uspto-grants-2013_02
Patent number
US08372976B2

Reaction notes

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