4-Piperidone → HCID 57821257, compound

HRID 388407Notes

Reaction equation

HRID 388407 reaction equation
Cl[CH2:2][C:3]1[NH:4][C:5](=[O:18])[C:6]2[C:11]([CH3:12])=[C:10]([C:13]([O:15]CC)=[O:14])[S:9][C:7]=2[N:8]=1.[NH:19]1[CH2:24][CH2:23][C:22](=[O:25])[CH2:21][CH2:20]1>>[CH3:12][C:11]1[C:6]2[C:5](=[O:18])[NH:4][C:3]([CH2:2][N:19]3[CH2:24][CH2:23][C:22](=[O:25])[CH2:21][CH2:20]3)=[N:8][C:7]=2[S:9][C:10]=1[C:13]([OH:15])=[O:14]

Participants

3

Reactant 2

HCID 337214-PiperidoneHCID 2339310Ethyl 2-(chloromethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylate

Product 1

HCID 57821257HCID 57821257, compound

Procedure

Using ethyl 2-chloromethyl-5-methyl-4-oxo-3,4-dihydrothieno-[2,3-d]pyrimidine-6-carboxylate and piperidin-4-one, a substitution reaction was carried out similarly to later appearing Production Example 21. Successively the reaction product was hydrolyzed similarly to Example 33, without intervening isolation of the reaction product, to provide the title compound.

Workup

  1. customa substitution reaction

Sources & evidence

ORD record
ord-0746f51183fd4898883ea8539c3cf10f
Source dataset
uspto-grants-2013_02
Patent number
US08377944B2

Reaction notes

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