反应详情

To a solution of 3-[1-(4,6-dimethyl-1,2-benzisothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl]-pentanoic acid methyl ester (65 mg, 0.14 mmol) in 1,4-dioxane (10 mL), THF (5 mL) and water (2 mL) is added LiOH (7 mg, 0.29 mmol) at room temperature. The solution is stirred at room temperature for 8 hours. The solution is concentrated and water is added to the residue. The solution is acidified by 12N HCl in an ice-bath. The precipitated solid filtration to afford the title compound.: LCMS (ESMS): m/z 438.09 (M+H+).

1. concentrationThe solution is concentrated
2. additionwater is added to the residue
3. customThe solution is acidified by 12N HCl in an ice-bath
4. filtrationThe precipitated solid filtration