反应详情

To a solution of 2,4,5-trifluoronitrobenzene (9.48 g) and benzyl alcohol (5.54 ml) in N,N-dimethylformamide (40 ml) was added potassium carbonate (11.1 g), and the mixture was stirred at room temperature for 60 hours. Water (120 ml) was added to the reaction mixture at 0° C. and the mixture was stirred at 4° C. for 24 hours. The precipitated crystals were collected by filtration and washed with water. The crystals were dried under reduced pressure to give the title compound (11.5 g, 81%) as pale yellow crystals.

1. stirringthe mixture was stirred at 4° C. for 24 hours
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed with water
4. customThe crystals were dried under reduced pressure