HCID 13519461, compound → HCID 68940045, compound

HRID 388742Notes

Reaction equation

HRID 388742 reaction equation
[OH:1][C:2]([CH3:21])([CH3:20])[C@H:3]([CH3:19])/[CH:4]=[CH:5]/[C@H:6]([C@@H:8]1[C@:16]2([CH3:17])[C@H:11]([C@@H:12]([OH:18])[CH2:13][CH2:14][CH2:15]2)[CH2:10][CH2:9]1)[CH3:7]>C(O)(=O)C.[Pt]>[OH:1][C:2]([CH3:20])([CH3:21])[C@H:3]([CH3:19])[CH2:4][CH2:5][C@H:6]([C@@H:8]1[C@:16]2([CH3:17])[C@H:11]([C@@H:12]([OH:18])[CH2:13][CH2:14][CH2:15]2)[CH2:10][CH2:9]1)[CH3:7]

Participants

4

Reactant 1

HCID 13519461HCID 13519461, compound

Product 1

HCID 68940045HCID 68940045, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 176Acetic AcidSolvent

Procedure

The compound of Example 15B (89 mg) was dissolved in acetic acid and hydrogenated over 10% platinum on carbon. After purging with nitrogen, the mixture was filtered through a pad of diatomaceous earth to remove catalyst and concentrated in vacuo to give material that was carried forward to the next step without further purification.

Workup

  1. customAfter purging with nitrogen
  2. filtrationthe mixture was filtered through a pad of diatomaceous earth
  3. customto remove catalyst
  4. concentrationconcentrated in vacuo
  5. customto give material that
  6. customwas carried forward to the next step without further purification

Sources & evidence

ORD record
ord-edb4a6a0735c4ca89473a01c81a4d43f
Source dataset
uspto-grants-2013_02
Patent number
US08377913B2

Reaction notes

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