Hydrochloric Acid → HCID 86620343, compound

HRID 388789Notes

Reaction equation

HRID 388789 reaction equation
C([O:3][C:4]([C:6]1([C:11]2[N:12]=[C:13]([NH:16][CH3:17])[S:14][CH:15]=2)[CH:10]=[CH:9][O:8][NH:7]1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[CH3:17][NH:16][C:13]1[S:14][CH:15]=[C:11]([C:6]2([C:4]([OH:5])=[O:3])[CH:10]=[CH:9][O:8][NH:7]2)[N:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86620341HCID 86620341, compound

Product 1

HCID 86620343HCID 86620343, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of ethyl-3-[2-(methylamino)-1,3-thiazol-4-yl]isoxazole-3-carboxylate (65 mg, 0.26 mmol) in ethanol (3.0 mL) was treated with 1N aqueous sodium hydroxide (0.30 mL, 0.28 mmol) and the mixture was stirred at room temperature for 2 h. The mixture was neutralized with 1 N aqueous hydrochloric acid and concentrated in vacuo to give the crude which was used without purification. MF=C8H7N3O3S; LCMS calculated for C8H7N3O3S (M+H)+: m/z=226.

Workup

  1. concentrationconcentrated in vacuo
  2. customto give the crude which
  3. customwas used without purification

Sources & evidence

ORD record
ord-3fdb6df42703444090a263c76f48061c
Source dataset
uspto-grants-2013_02
Patent number
US08377976B2

Reaction notes

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