Hydrochloric Acid → HCID 23658600, compound

HRID 388854Notes

Reaction equation

HRID 388854 reaction equation
[F:1][C:2]([F:35])([F:34])[C:3]1[CH:33]=[CH:32][C:6]([O:7][CH:8]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9][CH2:10][N:11]([CH3:25])[C:12]([CH2:14][CH2:15][CH2:16][NH:17]C(=O)OC(C)(C)C)=[O:13])=[CH:5][CH:4]=1.[ClH:36]>CCOC(C)=O>[ClH:36].[F:1][C:2]([F:34])([F:35])[C:3]1[CH:4]=[CH:5][C:6]([O:7][CH:8]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[CH2:9][CH2:10][N:11]([CH3:25])[C:12](=[O:13])[CH2:14][CH2:15][CH2:16][NH2:17])=[CH:32][CH:33]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 42637944HCID 42637944, compound

Product 1

HCID 23658600HCID 23658600, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

tert-Butyl 3-(N-(3-(4-(Trifluoromethyl)phenoxy)-3-phenylpropyl)-N-methyl carbamoyl)propylcarbamate (AN-229) was prepared as described in WO 2005/092392. AN-229 (0.5 mmol) was added to a solution of HCl in EtOAc (35 ml) and the resulting mixture was stirred for 3 hours. The solvent was thereafter evaporated and the product, AN-227, was obtained in quantitative yield.

Workup

  1. customThe solvent was thereafter evaporated
  2. customthe product, AN-227, was obtained in quantitative yield

Sources & evidence

ORD record
ord-1d46d8150deb45278889c8e0f3895343
Source dataset
uspto-grants-2013_02
Patent number
US08377990B2

Reaction notes

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