Hydrochloric Acid → HCID 131730234, compound

HRID 389276Notes

Reaction equation

HRID 389276 reaction equation
[CH2:1]([O:3][C:4](=[O:35])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([C:14]2[C:23]([CH2:24][N:25](C(OC(C)(C)C)=O)[CH2:26][CH3:27])=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH:7]=1)[CH3:2].[ClH:36]>C(Cl)Cl>[ClH:36].[ClH:36].[CH2:1]([O:3][C:4](=[O:35])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([C:14]2[C:23]([CH2:24][NH:25][CH2:26][CH3:27])=[CH:22][C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[N:15]=2)[CH:7]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58579957HCID 58579957, compound

Product 1

HCID 131730234HCID 131730234, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(3-{3-[(tert-Butoxycarbonyl-ethyl-amino)-methyl]-quinolin-2-yl}-4-methoxy-phenyl)-acetic acid ethyl ester (1.18 g, 2.46 mmol) in CH2Cl2 (10 mL) was treated with hydrogen chloride (4N in 1,4-dioxane; 5 mL, 20.0 mmol) at room temperature for 3 hours. The mixture was concentrated to give the title compound.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-32cbf3aef78c45da86b952a081d7049a
Source dataset
uspto-grants-2013_02
Patent number
US08378107B2

Reaction notes

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