Potassium Carbonate → HCID 178489989, compound

HRID 389306Notes

Reaction equation

HRID 389306 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH3:23])=[CH:5][C:6]([CH2:12][C:13]2[C:14]([CH3:22])=[N:15][N:16]([CH2:19][C:20]#[N:21])[C:17]=2[CH3:18])=[C:7]2[C:11]=1[CH2:10][CH2:9][CH2:8]2.Cl.[NH2:25][OH:26].C(=O)([O-])[O-].[K+].[K+]>CO.O>[OH:26][NH:25][C:20](=[NH:21])[CH2:19][N:16]1[C:17]([CH3:18])=[C:13]([CH2:12][C:6]2[CH:5]=[C:4]([CH3:23])[C:3]([O:2][CH3:1])=[C:11]3[C:7]=2[CH2:8][CH2:9][CH2:10]3)[C:14]([CH3:22])=[N:15]1

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 443297Hydroxyamine hydrochlorideHCID 66812260HCID 66812260, compound

Product 1

HCID 178489989HCID 178489989, compoundYield 81.4%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
70 °C

Procedure

To a stirred solution of [4-(7-Methoxy-6-methyl-indan-4-ylmethyl)-3,5-dimethyl-pyrazol-1-yl]-acetonitrile (2.0 gm 0.00647 mole) in methanol (50 ml), A suspension of Hydroxylamine hydrochloride (2.29 gm, 0.033 mole) and Potassium carbonate (4.37 gm, 0.0317 mole) in water (20 ml) was added. The reaction mixture was stirred for 30-36 hours at 70° C., cooled and then was filtered. The obtained solid was washed with water (10 ml) and finally with Hexane and dried under vacuum to give 1.8 gm of desired product

Workup

  1. additionwas added
  2. temperaturecooled
  3. filtrationwas filtered
  4. washThe obtained solid was washed with water (10 ml) and finally with Hexane
  5. customdried under vacuum

Sources & evidence

ORD record
ord-29a2104df65942189acc1e94f97fd94b
Source dataset
uspto-grants-2013_02
Patent number
US08378118B2

Reaction notes

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