反应详情

温度

27.5 °C

To a stirred suspension of 6-Methyl-7-hydroxy-indan-4-carbaldehyde (5 gm, 0.0284 mole) and Potassium carbonate (4.7 gm, 0.0340 mole) in dimethyl formamide, Methyl iodide (2.2 ml, 0.0312 mole) was added at 0° C. The reaction mixture was stirred at 25-30° C. for 4 hours, then water (200 ml) was added and extracted with Ethylacetate (2×100 ml). The Ethylacetate layer was dried over Sodium sulphate and evaporated to give a crude mass which was purified by column chromatography using Ethyl acetate:Hexane (10:90) as a mobile phase. The fractions were distilled under vacuum to give 4.8 gm of desired product as viscous oil.

1. additionwas added at 0° C
2. extractionextracted with Ethylacetate (2×100 ml)
3. dry with materialThe Ethylacetate layer was dried over Sodium sulphate
4. customevaporated
5. customto give a crude mass which
6. customwas purified by column chromatography
7. distillationThe fractions were distilled under vacuum