Ethyl 4-piperidinecarboxylate → HCID 67155380, compound

HRID 389656Notes

Reaction equation

HRID 389656 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH2:10][C@H:11]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][C:26]3=[O:31])[C:20]=2[O:32][CH:33]([F:35])[F:34])(=[O:18])=[O:17])[C:12](O)=[O:13])=[O:8])=[CH:4][CH:3]=1.[CH2:36]([O:38][C:39]([CH:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1)=[O:40])[CH3:37]>CN(C=O)C>[CH2:36]([O:38][C:39]([CH:41]1[CH2:46][CH2:45][N:44]([C:12](=[O:13])[C@@H:11]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][C:26]3=[O:31])[C:20]=2[O:32][CH:33]([F:34])[F:35])(=[O:18])=[O:17])[CH2:10][NH:9][C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)=[O:8])[CH2:43][CH2:42]1)=[O:40])[CH3:37]

Participants

4

Reactant 2

HCID 70770Ethyl 4-piperidinecarboxylateHCID 67155664HCID 67155664, compound

Product 1

HCID 67155380HCID 67155380, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Intermediate 34 (258 mg, 0.467 mmol) and Piperidine-4-carboxylic acid ethyl ester (81 mg, 0.514 mmol) were coupled in close analogy to the procedure described in 3.5) using DMF as solvent. The mixture was purified by prep. HPLC. Yield after lyophilization: 253 mg, 78%, colorless, amorphous solid.

Workup

  1. customThe mixture was purified by prep
  2. customYield after lyophilization

Sources & evidence

ORD record
ord-a1b67db7ff504ecd99b9801e5e3c4b35
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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