Hydrochloric Acid → HCID 72792817, compound

HRID 389671Notes

Reaction equation

HRID 389671 reaction equation
FC(F)(F)[C:3](O)=[O:4].C1(N2CCN([C:17](=[O:50])[C@@H:18]([NH:29]S(C3C=CC=C(N4CCCCC4=O)C=3OC(F)F)(=O)=O)[CH2:19][NH:20][C:21]([C:23]3[S:24][C:25]([Cl:28])=[CH:26][CH:27]=3)=[O:22])CC2)CC1.Cl>C(OCC)(=O)C>[ClH:28].[CH3:3][O:4][C:17](=[O:50])[C@@H:18]([NH2:29])[CH2:19][NH:20][C:21]([C:23]1[S:24][C:25]([Cl:28])=[CH:26][CH:27]=1)=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86653296HCID 86653296, compound

Product 1

HCID 72792817HCID 72792817, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

33 g (110.24 mmol) of intermediate 8 from step 22.4) were dissolved in 600 ml ethyl acetate and 250 ml HCl (2N in diethyl ether) was added. After 20 h stirring at RT the reaction was filtered and the solid dried under reduced pressure.

Workup

  1. filtrationwas filtered
  2. customthe solid dried under reduced pressure

Sources & evidence

ORD record
ord-f314a783555c40878ff6832da60ad738
Source dataset
uspto-grants-2013_02
Patent number
US08378092B2

Reaction notes

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