反应详情

温度

130 °C

To a solution of 579 mg of 3-[2,5-dioxo-4-[(2-propenyloxy)methyl]imidazolidin-4-yl]benzonitrile and 534 mg of 4-bromo-2-(trifluoromethyl)benzonitrile in DMAC (2.5 mL), 183 mg of copper oxide are added. The mixture is refluxed overnight at 130° C. The mixture is concentrated, taken in DCM, washed with a solution of 10% aqueous ammonia solution and brine. The organic phase is dried over magnesium sulfate, concentrated under vacuum and purified on silica gel (ethyl acetate/cyclohexane 0/100 to 50/50) to give the desired compound.

1. concentrationThe mixture is concentrated
2. washwashed with a solution of 10% aqueous ammonia solution and brine
3. dry with materialThe organic phase is dried over magnesium sulfate
4. concentrationconcentrated under vacuum
5. custompurified on silica gel (ethyl acetate/cyclohexane 0/100 to 50/50)