反应详情

p-Toluidine (10.407 g, 97.116 mmol) was dissolved in anhydrous acetonitrile and, after adding potassium carbonate (49.9 g, 361.272 mmol), stirred at room temperature for 10 minutes. After slowly adding 4-bromobutyronitrile (10.1 mL, 101.972 mmol) to the resultant reaction mixture, reaction was carried out at 100° C. for 2 days. The mixture was cooled to room temperature and the produced solid was removed by filtering. The filtrate was concentrated under reduced pressure. A target compound (13.23 g, 78.2%) was yielded. A target compound was used in the next step without further purification.

1. waitwas carried out at 100° C. for 2 days
2. temperatureThe mixture was cooled to room temperature
3. customthe produced solid was removed
4. filtrationby filtering
5. concentrationThe filtrate was concentrated under reduced pressure