Potassium Carbonate → 3-amino-1-[{4-(2,4-dimethylphenyl)piperazin-1-yl}propanoyl]-6-N-{(furan-2-yl)methyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one

HRID 390029Notes

Reaction equation

HRID 390029 reaction equation
[NH2:1][C:2]1[C:10]2[CH2:9][CH2:8][N:7]([CH2:11][C:12]3[O:13][CH:14]=[CH:15][CH:16]=3)[C:6](=[O:17])[C:5]=2[NH:4][N:3]=1.[C:18](=[O:21])([O-])[O-].[K+].[K+].ClC[CH2:26][C:27]([N:29]1[CH2:34][CH2:33][N:32]([C:35]2[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][C:36]=2[CH3:42])[CH2:31][CH2:30]1)=O>>[NH2:1][C:2]1[C:10]2[CH2:9][CH2:8][N:7]([CH2:11][C:12]3[O:13][CH:14]=[CH:15][CH:16]=3)[C:6](=[O:17])[C:5]=2[N:4]([C:18](=[O:21])[CH2:26][CH2:27][N:29]2[CH2:34][CH2:33][N:32]([C:35]3[CH:40]=[CH:39][C:38]([CH3:41])=[CH:37][C:36]=3[CH3:42])[CH2:31][CH2:30]2)[N:3]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 679969813-amino-6-N-((furan-2-yl)methyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-oneHCID 679970803-Chloro-1-{4-(2,4-dimethylphenyl)piperazin-1-yl}propan-1-one

Product 1

HCID 679970083-amino-1-[{4-(2,4-dimethylphenyl)piperazin-1-yl}propanoyl]-6-N-{(furan-2-yl)methyl}-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-7-one

Procedure

A target compound (187.7 mg, 0.393 mmol, 93.3%) was yielded as solid in the same manner as Example 1 by reacting 3-amino-6-N-((furan-2-yl)methyl)-5,6-dihydro-1H-pyrazolo[3,4-c]pyridin-7(4H)-one (98 mg, 0.422 mmol) with potassium carbonate (87.4 mg, 0.633 mmol) and 3-chloro-1-{4-(2,4-dimethylphenyl)piperazin-1-yl}propan-1-one (130.2 mg, 0.464 mmol).

Sources & evidence

ORD record
ord-99897fa424134a518f41fac3a3ac8b4f
Source dataset
uspto-grants-2013_02
Patent number
US08383631B2

Reaction notes

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