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HRID390033

反应详情

EQUATION

反应方程式

HRID 390033 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])CCC(=O)[O-].[Na+].[Na+]
HCID9020

Disodium succinate

C4H4Na2O4

结构：Cl.Cl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
HCID55182

Cetirizine hydrochloride (1:2)

C21H27Cl3N2O3

结构：OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO
HCID444041

beta-Cyclodextrin

C42H70O35

PRODUCTS

生成物

1
结构：O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
HCID2678

Cetirizine

C21H25ClN2O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

As indicated in Table 1, Cetirizine Dihydrochloride, Beta-cyclodextrin, Sodium Succinate, and Corn Starch are charged into a Fluid Bed Granulator. Approximately 3000 g of Purified Water is then sprayed into the bed at approximately 75-125 g/minute and an inlet air temperature of approximately 55° C., using an atomization air pressure of 2 bar. Approximately 5680 g of the solution prepared in Step A is then sprayed onto the granulation at approximately 75 to 125 g/minute, using an inlet air temperature of approximately 55° C., using an atomization air pressure of 2 bar. Following spraying, the granulation is dried to a product temperature endpoint of approximately 30° C., or a Loss on Drying Analysis (LOD) of approximately 7.5%.

WORKUP

后处理

  1. additionare charged into a Fluid Bed Granulator
  2. customis then sprayed into the bed at approximately 75-125 g/minute and an inlet air temperature of approximately 55° C.
  3. customair temperature of approximately 55° C.
  4. customthe granulation is dried to a product temperature endpoint of approximately 30° C.
  5. customa Loss on Drying Analysis (LOD) of approximately 7.5%