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HRID390035

反应详情

EQUATION

反应方程式

HRID 390035 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])CCC(=O)[O-].[Na+].[Na+]
HCID9020

Disodium succinate

C4H4Na2O4

结构：Cl.Cl.O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
HCID55182

Cetirizine hydrochloride (1:2)

C21H27Cl3N2O3

结构：OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]8CO)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO
HCID444041

beta-Cyclodextrin

C42H70O35

PRODUCTS

生成物

1
结构：O=C(O)COCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1
HCID2678

Cetirizine

C21H25ClN2O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A 65 L TK Fielder high sheer granulator equipped with a chopper is used for high shear granulation. The Cetirizine Dihydrochloride, Beta-cyclodextrin, PVP and Sodium Succinate are charged into the granulator and mixed for approximately 1 minute while with the chopper active. 1000 g of purified water is slowly added over 2 minutes while mixing and with the chopper active. The Corn Starch is then added and allowed to mix for 1 minute. The granulation is then dried in a Glatt GCPG 15 kg drying unit to a final LOD of approximately 7%.

WORKUP

后处理

  1. customA 65 L TK Fielder high sheer granulator equipped with a chopper
  2. additionmixed for approximately 1 minute while with the chopper active
  3. additionwhile mixing
  4. additionto mix for 1 minute
  5. customThe granulation is then dried in a Glatt GCPG 15 kg
  6. customdrying unit to a final LOD of approximately 7%