反应详情

温度

75 °C

To a solution of 1,1-dimethylethyl[3-(3-aminophenyl)propyl]carbamate (390 mg, 1.558 mmol) in DMF (5 mL) were added ethyl 4-chloro-6-methyl-2-(methylthio)-5-pyrimidinecarboxylate (307 mg, 1.246 mmol) and DIEA (0.298 mL, 1.714 mmol), and the reaction mixture was stirred at 75° C. overnight. The reaction was then concentrated and the residue was purified using column chromatography (silica gel, 0% to 50% EtOAc gradient in hexane) to afford the product (210 mg, 29% yield).

1. concentrationThe reaction was then concentrated
2. customthe residue was purified