Trifluoroacetic acid → HCID 44818184, compound

HRID 390044Notes

Reaction equation

HRID 390044 reaction equation
C(O)(C(F)(F)F)=O.CC([N:12]([CH2:16][CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([NH:25][C:26]2[C:27]3[C:47](=[O:48])[NH:46][CH:45]=[CH:44][C:28]=3[N:29]=[C:30]([NH:32][CH2:33][CH2:34][CH2:35][NH:36]C(OC(C)(C)C)=O)[N:31]=2)[CH:20]=1)C(=O)[O-])(C)C>ClCCl>[NH2:36][CH2:35][CH2:34][CH2:33][NH:32][C:30]1[N:31]=[C:26]([NH:25][C:21]2[CH:22]=[CH:23][CH:24]=[C:19]([CH2:18][CH2:17][CH2:16][NH2:12])[CH:20]=2)[C:27]2[C:47](=[O:48])[NH:46][CH:45]=[CH:44][C:28]=2[N:29]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86654200HCID 86654200, compound

Product 1

HCID 44818184HCID 44818184, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a premixed solution of TFA (0.5 mL, 6.49 mmol) and dichloromethane (0.5 mL) was added to 1,1-dimethylethyl(3-{3-[(2-{[3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)propyl]amino}-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-4-yl)amino]phenyl}propyl)carbamate (39 mg, 0.069 mmol) and the mixture was stirred for 30 min. It was then concentrated and the product was lyophilized (30 mg, white solid).

Workup

  1. concentrationIt was then concentrated

Sources & evidence

ORD record
ord-0322c7df847d46508154aed77d78f96e
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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