Trifluoroacetic acid → HCID 44818185, compound

HRID 390046Notes

Reaction equation

HRID 390046 reaction equation
C(O)(C(F)(F)F)=O.CC([N:12]([CH2:16][CH2:17][CH2:18][NH:19][C:20]1[N:21]=[C:22]([NH:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([CH2:38][CH2:39][NH2:40])[CH:33]=2)[C:23]2[C:29](=[O:30])[NH:28][CH:27]=[CH:26][C:24]=2[N:25]=1)C(=O)[O-])(C)C>ClCCl>[NH2:40][CH2:39][CH2:38][C:34]1[CH:33]=[C:32]([NH:31][C:22]2[C:23]3[C:29](=[O:30])[NH:28][CH:27]=[CH:26][C:24]=3[N:25]=[C:20]([NH:19][CH2:18][CH2:17][CH2:16][NH2:12])[N:21]=2)[CH:37]=[CH:36][CH:35]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86654201HCID 86654201, compound

Product 1

HCID 44818185HCID 44818185, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a premixed solution of TFA (0.5 mL, 6.49 mmol) and dichloromethane (0.5 mL) was added to 1,1-dimethylethyl{3-[(4-{[3-(2-aminoethyl)phenyl]amino}-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl)amino]propyl}carbamate (11 mg, 0.024 mmol) and the reaction mixture was stirred for 30 min. It was concentrated and the product lypholized (4 mg, white solid).

Workup

  1. concentrationIt was concentrated

Sources & evidence

ORD record
ord-5296a0edc190427fa284c23a59ce8a93
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

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