Trifluoroacetic acid → HCID 44818005, compound

HRID 390051Notes

Reaction equation

HRID 390051 reaction equation
CC([N:5]([CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:14]=[C:15]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=2)[C:16]2[C:22](=[O:23])[NH:21][CH:20]=[CH:19][C:17]=2[N:18]=1)C(=O)[O-])(C)C.C(O)(C(F)(F)F)=O>ClCCl>[NH2:5][CH2:9][CH2:10][CH2:11][NH:12][C:13]1[N:14]=[C:15]([NH:24][C:25]2[CH:30]=[CH:29][CH:28]=[C:27]([CH3:31])[CH:26]=2)[C:16]2[C:22](=[O:23])[NH:21][CH:20]=[CH:19][C:17]=2[N:18]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86654202HCID 86654202, compound

Product 1

HCID 44818005HCID 44818005, compoundYield 133.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-dimethylethyl[3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]carbamate (245 mg, 0.577 mmol) was dissolved into dichloromethane (3 mL) and TFA (1 mL) was added. The reaction mixture was stirred for 1 h and concentrated. The residue was further dried under high vacuum to afford the product as a TFA salt (250 mg).

Workup

  1. additionwas added
  2. concentrationconcentrated
  3. customThe residue was further dried under high vacuum

Sources & evidence

ORD record
ord-2396b788e5b54b66b2380d554709662b
Source dataset
uspto-grants-2013_02
Patent number
US08383635B2

Reaction notes

Loading…